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Jurnal Farmasi Sains dan Praktis
Published by Universitas Muhammadiyah Magelang
ISSN : 25499068     EISSN : 25794558     DOI : -
Core Subject : Health, Science,
Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Farmasi Sains dan Praktis aims to serve the updated scientific knowledge for international researchers in pharmaceutical sciences. Jurnal Farmasi Sains dan Praktis (JFSP) publishes review article, original article, as well as short communication in the all scopes of Pharmaceutical Science such as Pharmaceutics, Biopharmaceutics, Drug Delivery System, Physical Pharmacy, Pharmaceutical Technology, Pharmaceutical Microbiology and Biotechnology, Pharmacology and Toxicology, Pharmacokinetics, Pharmaceutical Chemistry, Pharmaceutical Biology, Community and Clinical Pharmacy, Pharmaceutical Marketing, Alternative Medicines, Pharmaceutical Management, Pharmacoeconomic, Pharmacoepidemiology, Social Pharmacy, Pharmacy Policies.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 14 Documents
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Search results for , issue "Vol 8 No 3 (September-December 2022)" : 14 Documents clear
KNOWLEDGE, ATTITUDES, AND BEHAVIOR OF THE COMMUNITY IN USING SUPPLEMENTS DURING THE COVID-19 PANDEMIC Yeni Farida; Rasmaya Niruri; Adi Yugatama
Jurnal Farmasi Sains dan Praktis Vol 8 No 3 (September-December 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i3.4251

Abstract

The Covid-19 pandemic has been responded to various attitudes and behaviors related to its prevention. Understanding certain information makes a person make the right decision. Misunderstanding the improvement of the immunity system and prevention of COVID-19 may lead to inappropriate attitudes and behaviors in using supplements in society. This study aims to describe the level of knowledge and attitudes toward using health supplements and the consumption of health supplements during the Covid-19 pandemic. The research design is a cross-sectional study using primary data based on data collection by questionnaire. The research subjects were visitors of Jamsaren and Riyadh pharmacies in September 2020 who were more than 17 years old, could read and write, and were willing to be respondents. Knowledge is assessed by each correct answer marked 1, and then the total is compared with the total score multiplied by 100%. The level of knowledge is classified based on the score obtained; poor knowledge (score <70) and good (>70). Attitudes are classified into panic and non-panic. Behavior was analyzed descriptively. The results on 132 subjects showed that most of the respondents (78%) still had less knowledge of using health supplements to prevent Covid-19. The Chi-Square test results obtained a p-value of 0.312 (p > 0.05), meaning no significant difference in knowledgeable or good knowledge in respondents' responses. The attitude variable affects the respondent's behavior, as evidenced by the p-value of 0.008 (p <0.05). The predominant health supplement is vitamin C from pharmacies on their initiative
THE RELATIONSHIP BETWEEN SIDE EFFECTS OF TUBERCULOSIS DRUG USE AND SGOT/SGPT VALUE OF INTENSIVE PHASE PATIENTS Farroh Bintang Sabiti; Nur Anna Chalimah Sa’dyah
Jurnal Farmasi Sains dan Praktis Vol 8 No 3 (September-December 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i3.4721

Abstract

Tuberculosis is an infectious disease caused by the bacteria Mycobacterium Tuberculosis which has a rod shape and is acid-resistant. The prolonged consumption of anti-tuberculosis drugs can cause serious side effects. Side effects from the consumption of anti-tuberculosis drugs, namely the risk of hepatotoxicity, which is marked by an increase in the SGOT / SGPT value. This study aimed to determine the relationship between the duration of use, dosage and side effects of anti-tuberculosis drugs in tuberculosis patients, which had an effect on the SGOT / SGPT value at RSI Sultan Agung Semarang. This research is an analytical observational study with a cross-sectional design. The sample was 96 patients, and data collection was carried out in January-November 2020 at RSI Semarang. The instrument used in this study was patient medic record data. This study uses the Chi-Square test. The Chi-Square test results in 0.000 (p <0.05) so that it could be stated that there was a relationship between the use and side effects on the SGOT / SGPT value.
NANOEMULSION CHARACTERISTICS PREPARATIONS ETHANOL LEAF EXTRACTS IN VARIOUS PLANTS: LITERATURE REVIEW Nora Nur Aini; Ratna Wijayatri; Prasojo Pribadi
Jurnal Farmasi Sains dan Praktis Vol 8 No 3 (September-December 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i3.4786

Abstract

Nanoemulsion is one of the nanotechnology applications that can measure particles 0-100 nm which has control of the release of active ingredients and good sensory properties. Nanoemulsion of ethanol leaf extract in various plants has considerable potential in the utilization of natural materials. The solvent used is an important factor. This research focuses on plant leaf parts with ethanol extract. The purpose of this review is to study, evaluate and analyze literature focused on the characteristics of nanoemulsion preparations of ethanol leaf extracts in various plants related to nanoemulsion components, manufacturing methods, and nanoemulsion preparation characteristics. This research uses the method of literature review or narrative review, the search for published scientific literature is indexed in various databases. Search articles through various databases to ensure that the majority of relevant studies have been identified. Based on the results of the literature review concluded that the most widely used surfactant in the review of these articles is Polysorbat 80 or Tween 80 which is a non-ionic and non-irritative surfactant commonly used in pharmaceutical and cosmetic preparations. Ultrasonification and microfluidation methods are also applied in some articles because they are capable of producing a minimum droplet diameter of 150 to 170 nm..The results of the study of particle size in the article produced particle sizes between 10.9 nm-312.1 nm. Indeks polidispersitas value 0.08-0.7 zeta potential value above +/-30 and EE value shows value above 80%. It can be concluded that the nanoemulsion characteristics of each article meet the requirements and produce stable nanoemulsions.
OPTIMIZATION OF CROSCARMELLOSE AND SODIUM STARCH GLYCOLATE ON ORALLY DISINTEGRATING METOCLOPRAMIDE HCL TABLETS Endang Diyah Ikasari; Intan Martha Cahyani; Deby Melinda Collusy
Jurnal Farmasi Sains dan Praktis Vol 8 No 3 (September-December 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i3.4830

Abstract

Dosage form of metoclopramide HCl which has high solubility but low permeability is Orally Disintegrating Tablet (ODT), because can decrease first-pass-effect metabolism so that its bioavailability and effectiveness increase. Superdisintegrant is an excipient that has a major role in the formulation of ODT. The combination of croscarmellose and Sodium Starch Glycolate (SSG) can accelerate tablet disintegration time so that the resulting ODT is suitable for its intended use. The purpose of this study was to determine the effect of each and the interaction of the use of croscarmellose and SSG on the physical characteristics of ODT metoclopramide HCl, and to get the optimum formula of ODT metoclopramide HCl. Tablets were prepared by direct compression method. Optimization process by using simplex lattice design (design expert 10.0.1.R program) with eight formulas, including FI (5.25%A:1.75%B), FII (0%A:7%B), FIII (7%A:0%B), FIV (1,75%A:5,25%B), FV (7%A:0%B), FVI (3.5%A:3.5%B), FVII (3.5%A:3.5%B) and FVIII (0%A:7%B). Component A is the concentration of croscarmellose and component B is the concentration of SSG. Based on SLD equation could be seen the single-use croscarmellose and SSG components be increased flowability, hardness, moisture content, friability, water ratio absorption, weight uniformity, uniformity of content, accelerate disintegration time, wetting time, and dissolution. Interaction of the two components was increased flowability, moisture content, water ratio absorption and dissolution, decreased hardness, friability, uniformity of content, weight uniformity, accelerate disintegration time, and wetting time. The optimum formula of ODT metoclopramide HCl with proportion 5.145% croscarmellose and 1.855% SSG. Based on the one sample t-test between theoretical results and the experimental results could be seen that there were no significant differences between them
DETERMINANT FACTORS OF PATIENT SATISFACTION AND TRUST IN PHARMACY STAFF AMONG PERSONS WITH NON-COMMUNICABLE DISEASES: PATIENT CENTERED CARE APPROACH Siti Rahayu Nurjanah; Prasojo Pribadi; Puspita Septie Dianita
Jurnal Farmasi Sains dan Praktis Vol 8 No 3 (September-December 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i3.5150

Abstract

Patient satisfaction and trust are the main focus in the context of health care. Patient satisfaction is influenced by medication service factors, handling patient complaints and listening to patient needs. Important to develop and test a patient-centered care model as a tool to monitor, measure, analyze, and increase patient satisfaction and trust among people with non-communicable diseases in Public Health Center service setting. This study attempts to ascertain the effect of care on patient satisfaction and trust in pharmacy staff at the Magelang City Public Health Center. Cross-sectional quantitative research is used in this field. 212 people participated as the sample. Non-probability sampling using a purposive sample strategy was used as the sampling technique in this investigation. Structural Equation Modeling-Partial Least Square (SEM-PLS) is used for hypothesis testing. According to the study's findings, patient satisfaction is positively impacted by pharmacy staffs’ participative behavior and interpersonal communication (p< 0.05). Interpersonal communication and pharmacy staff participation do not affect the trust in pharmacy staff (p> 0.05). Patient satisfaction plays a moderating role in the association between pharmacy staff participation and trust in pharmacy staff (p< 0.05). Likewise, the association between interpersonal communication and trust in pharmacy staff is mediated by patient satisfaction (p< 0.05).
DETECTION OF SALMONELLA TYPHIMURIUM BACTERIA ON BAKERY PRODUCTS SAMPLES USING BOILING ISOLATION TECHNIQUE Alfi Sophian; Ratna Purwaningsih; Muhammad Tri Sutrisno; Purwadi Purwadi; Arif Wahyudi
Jurnal Farmasi Sains dan Praktis Vol 8 No 3 (September-December 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i3.5550

Abstract

Detection of Salmonella typhimurium ATCC 14028 bacteria in bakery product samples by real-time PCR using boiling isolation technique. The basis of this research is to have an impact on economic value in carrying out the confirmation test for Salmonella typhimurium ATCC 14028, where testing is carried out conventionally will require large costs, so it is necessary to innovate in terms of modifying the testing phase so that it is more effective and efficient. The purpose of this study was to see whether the boiling isolation technique could be used for the detection test for Salmonella typhimurium ATCC 14028 on bacterial product samples. The sample in this study consisted of 15 types of bacterial product samples spiked with Salmonella typhimurium ATCC 14028 cultures that had been cultured into phase 2 working cultures. The method used in this study was qPCR analysis using the SYBR Green method. The results of real-time PCR analysis obtained Ct values in the range 7.55 - 8.91 with an average of 8.28 and a Tm value in the range 85.50 - 86.20 with an average of 85.77 Based on these data it can be concluded that the detection of Salmonella typhimurium bacteria ATCC 14028 with real-time PCR using boiling isolation technique can be applied for testing on bakery product samples.
PRESCRIPTION COST ANALYSIS IN PATIENTS WITH HYPERTENSION AND TYPE 2 DIABETES MELITUS AFTER THE IMPLEMENTATION OF INDONESIAN NATIONAL HEALTH INSURANCE Indriyati Hadi Sulistyaningrum; Arifin Santoso; Kusuma Arbianti; Garnes Mona Yulieta
Jurnal Farmasi Sains dan Praktis Vol 8 No 3 (September-December 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i3.5956

Abstract

Chronic disease is a long-term health condition that requires on-going medical attention, and is classified as a non-communicable disease. The long-term medical treatment for chronic diseases, such as type 2 diabetes mellitus and hypertension is considerably costly. This study aims to determine the real cost and pattern of drug prescribing as well as the factors affecting the real Prescription Cost for hypertension and type 2 diabetes mellitus after the implementation of Indonesian National Health Insurance (JKN) as seen from the practice of Independent Physicial in collaboration with BPJS Kesehatan (Healthcare and Social Security Agency). This is a non-experimental (observational) study. The data were collected using purposive sampling method with 147 medical prescriptions as the research samples for each type of disease from the patient's medical record. Data were analyzed descriptively to determine Prescription Costs and spearman's rho test was used to determine the factors that influence Prescription Costs. The study revealed that the average Prescription Cost for type 2 DM patients was Rp17,806,- and Rp12,946 for hypertensive patients. Factors that affected Prescription Cost were diagnosis (p= 0.026), type of medicine (p= 0.000) and drug items (p= 0.000). This study concludes that patients with diabetes mellitus were treated with the drug prescription pattern of a combination of metformin and glimepiride, while patients with hypertension were provided with amlodipine. The real Prescription Cost is influenced by several factors, including; the patient's diagnosis, the type of drug given and the number of drug items provided to patients.
SIMULTANEOUS CONTENT ANALYSIS OF RIFAMPICIN, ISONIAZID, AND PYRAZINAMIDE IN TABLET DOSAGE FORM BY SPECTROPHOTOMETRY ULTRAVIOLET WITH DWM AND RSM Luthvia Luthvia; Muhammad Andry
Jurnal Farmasi Sains dan Praktis Vol 8 No 3 (September-December 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i3.6241

Abstract

Treatment of active tuberculosis requires the use of combinations of drugs. One of the common combination of drugs to serve as anti-tubercular medication is rifampin, isoniazid and pyrazinamide. However, a research conducted by the Food Drug Administration (FDA) concluded that the combination of anti-tubercular medication may pose some patients to the risk of sub-optimal drug exposure, which may lead to less optimal treatment. This study aimed to determine the drug level of combination of anti-tubercular medication, namely rifampin, isomiazid, and pyrazinamide and to develop a spectrophotometric method using the dual wavelength method (DWM) and ratio substaction method (RSM) in tablet preparations on the market without separation. During the preparation, methanol was used as the solvent, followed by dilution, determination of calibration curve, determination of wavelength (λ), measurement, data analysis and validity test with several parameters ranging from linearity, accuracy, precision, LOD, and LOQ. The research revealed that the drug levels of rifampin, isoniazid, and pyrazinamide from the ultraviolet spectrophotometric method using sequential DWM were 100.3±1.8785; 99.98±2.5943; 100.03±2.076 and the results of the ultraviolet spectrophotometric method using RSM sequentially were 99.73±0.5437; 99.84±1.7598; 99.91±1.4762. Both methods succeeded in determining the drug level of the combination of rifampin, isoniazid, and pyrazinamide in tablet preparations without separation and the results of the validation parameters met the requirements.
VALIDATION OF SPECTROPHOTOMETRIC METHOD TO QUANTIFY QUERCETIN IN THE IN VITRO DISSOLUTION STUDY OF SELF NANO-EMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) Wildan Khairi Muhtadi; Ferdy Firmansyah; Tiara Tri Agustini; Pricillia Rahayu; Siti Arifah Fitriyanti; Rodhia Ulfa
Jurnal Farmasi Sains dan Praktis Vol 8 No 3 (September-December 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i3.6258

Abstract

Quercetin possesses low solubility and decreases oral bioavailability. One way to increase the bioavailability of quercetin is by formulating a self-nanoemulsifying drug delivery system (SNEDDS). In vitro dissolution testing of SNEDDS needs to be carried out using a validated analytical method. This study aims to validate the quercetin analytical method in in vitro dissolution testing. Validation was carried out with two solvents, namely hydrochloric acid buffer pH 1.2 (HCl-1,2) and phosphate buffer pH 6.8 (PO-6.8). It tested some parameters, including linearity, detection limit (LoD), quantification limit (LoQ), accuracy, and precision. The quercetin calibration curve for both solvents has a value of r≥0.999. The LoD at HCl-1,2 and PO-6,8 were 0.26 ppm and 0.27 ppm, respectively. The LoQ of HCl-1,2 and PO-6,8 were 0.86 ppm and 0.91 ppm, respectively. The percentage recovery in both solvents was in the range of 80-110%. The relative standard deviation of the two solvents was less than 7.3%. The quercetin analytical method has been successfully validated as indicated by the results of linearity, detection limit, quantification limit, accuracy, and precision that met the requirements
SINERGISTIC COMBINATION OF ALOE VERA AND KERSEN LEAF EXTRACTS FOR INHIBITION OF THE GROWTH OF Staphylococcus aureus 25923 Nanik Sulistyani; Zikri Almahdi; Zainab -; Alfian Syarifuddin
Jurnal Farmasi Sains dan Praktis Vol 8 No 3 (September-December 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i3.6268

Abstract

Aloe vera leaf (Aloe vera L.) and cherry leaf (Muntingia calabura L.) contain bioactive compounds that serve as the potential antibacterial agent. The combination treatment of multiple extracts can produce a stronger effect than a single compound. This study aims to determine the synergistic combination of aloe vera leaf extract (EDLB) and cherry leaf extract (EDK) as an antibacterial agent against Staphylococcus aureus ATCC 25923. The extract was obtained by maceration using 96% ethanol. Chemical content in the extract was analyzed by tube test and thin layer chromatography (TLC). Antibacterial activity against S. aureus ATCC 25923 was measured by the checkerboard microdilution method on a 96 well microplate. The effect of the combination of extracts on antibacterial activity was based on the fractional inhibitory concentration index (FICI) value. EDLB and EDK contain flavonoids, tannins, alkaloids, and saponins. The second combination showed a synergistic effect with a FICI value of 0.5 in inhibiting the growth of S. aureus with minimal inhibitory levels in a mixture of 0.625 mg/mL EDLB and 2.5 mg/mL EDK.

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